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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
GUCY1A3
All Species:
16.36
Human Site:
S108
Identified Species:
30
UniProt:
Q02108
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.33
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q02108
NP_000847.2
690
77452
S108
K
I
K
E
S
R
K
S
L
E
R
E
D
F
E
Chimpanzee
Pan troglodytes
XP_522169
734
81883
R126
E
H
Q
V
I
G
Y
R
D
A
E
K
N
F
Y
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_536590
746
83063
R138
E
H
Q
V
I
G
Y
R
D
A
E
R
N
F
H
Cat
Felis silvestris
Mouse
Mus musculus
Q9ERL9
691
77555
S108
K
I
E
E
N
R
K
S
S
E
K
E
D
L
E
Rat
Rattus norvegicus
P19686
690
77548
S107
K
I
K
E
N
R
N
S
S
E
K
E
D
L
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001510214
690
77963
S108
K
I
K
E
N
R
K
S
L
E
K
E
D
F
E
Chicken
Gallus gallus
XP_420375
688
77848
I106
R
I
K
E
T
R
N
I
G
D
R
E
D
F
E
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_002667138
626
69572
F93
A
L
Q
R
T
V
E
F
Y
R
Q
R
E
I
S
Tiger Blowfish
Takifugu rubipres
NP_001027855
675
75480
S114
C
T
E
Y
Q
R
C
S
D
D
P
E
H
F
V
Fruit Fly
Dros. melanogaster
Q07093
676
75644
K104
D
I
Q
E
L
L
L
K
M
D
E
A
S
A
S
Honey Bee
Apis mellifera
NP_001011650
699
78655
N111
S
L
E
K
L
L
C
N
V
E
A
E
E
N
Y
Nematode Worm
Caenorhab. elegans
O02298
688
78384
R118
V
V
Y
K
T
K
L
R
G
P
S
F
R
C
D
Sea Urchin
Strong. purpuratus
P16065
1125
126238
Y314
R
L
F
K
N
R
E
Y
T
R
S
D
N
D
R
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
47.9
N.A.
47.3
N.A.
89.5
89.2
N.A.
87.5
84
N.A.
39.1
58.9
34.2
35
29.5
22.6
Protein Similarity:
100
63
N.A.
62.4
N.A.
94.9
94.9
N.A.
93.4
92.3
N.A.
54.3
73.6
53.3
55.3
48.2
36.3
P-Site Identity:
100
6.6
N.A.
6.6
N.A.
66.6
66.6
N.A.
86.6
60
N.A.
0
26.6
13.3
13.3
0
6.6
P-Site Similarity:
100
33.3
N.A.
26.6
N.A.
86.6
80
N.A.
100
80
N.A.
40
40
33.3
53.3
33.3
53.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
0
0
0
0
0
0
0
0
16
8
8
0
8
0
% A
% Cys:
8
0
0
0
0
0
16
0
0
0
0
0
0
8
0
% C
% Asp:
8
0
0
0
0
0
0
0
24
24
0
8
39
8
8
% D
% Glu:
16
0
24
47
0
0
16
0
0
39
24
54
16
0
39
% E
% Phe:
0
0
8
0
0
0
0
8
0
0
0
8
0
47
0
% F
% Gly:
0
0
0
0
0
16
0
0
16
0
0
0
0
0
0
% G
% His:
0
16
0
0
0
0
0
0
0
0
0
0
8
0
8
% H
% Ile:
0
47
0
0
16
0
0
8
0
0
0
0
0
8
0
% I
% Lys:
31
0
31
24
0
8
24
8
0
0
24
8
0
0
0
% K
% Leu:
0
24
0
0
16
16
16
0
16
0
0
0
0
16
0
% L
% Met:
0
0
0
0
0
0
0
0
8
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
31
0
16
8
0
0
0
0
24
8
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
8
8
0
0
0
0
% P
% Gln:
0
0
31
0
8
0
0
0
0
0
8
0
0
0
0
% Q
% Arg:
16
0
0
8
0
54
0
24
0
16
16
16
8
0
8
% R
% Ser:
8
0
0
0
8
0
0
39
16
0
16
0
8
0
16
% S
% Thr:
0
8
0
0
24
0
0
0
8
0
0
0
0
0
0
% T
% Val:
8
8
0
16
0
8
0
0
8
0
0
0
0
0
8
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
8
8
0
0
16
8
8
0
0
0
0
0
16
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _